Recent study finds the Topi-CLICK Perl® Vaginal Dosing System is more accurate than traditional vaginal dosing methods

July 10th, 2019

Woodstock (Atlanta), Ga.

A recent scientific study concludes that Topi-CLICK Perl® Vaginal Dosing System delivers doses of feminine cream at a high level of accuracy and precision, outperforming other tested devices in all measures.

The scientific research, Single-Blinded Feminine Dosing Study¹, conducted by Analytical Research Laboratories (ARL) in Oklahoma City, Okla., evaluated the accuracy, precision, and residual of medication dispensed using different dosing methods for topical feminine medications. Ease-of-use based on testers’ observations during each dispensing cycle was a secondary objective of the study.

Five different types of vaginal cream loaders and applicator combinations were tested to measure the percentage of
1 mL and 4 mL doses delivered within 10% of the upper and lower limits of the target rate. Tested devices included the Topi-CLICK Perl®, Plastic Tube/Ribbed Applicator, PlasticTube/Smooth Applicator, Metal Tube/Ribbed Applicator and Metal Tube/Smooth Applicator.

Results concluded that Topi-CLICK Perl® delivered doses within the 10% target rate with an average of 87.8-88.3% for 1 mL and 4 mL with few occurrences of delivering outside the 10% reference range. Topi-CLICK Perl® out-performed the traditional Plastic and Metal tube vaginal dosing systems by a significant margin and had 36% less medication wasted on average. Plastic Tubes with both the Ribbed Applicator and the Smooth Applicator showed inconsistent dosing with cycles of overdosing as well as several occurrences of delivering doses below the 10% target dose. Overdosing also occurred with the Metal Tubes/Ribbed Applicator and Metal Tubes/Smooth Applicator.

Testers observed that the Topi-CLICK Perl® was the easiest to use of all vaginal dosing systems in the study. Plastic tubes required frequent priming and were difficult for operators to squeeze. Metal tubes tended to be messy and cream continued to dispense even after pressure was released.

Tim Phipps, President of DoseLogix, said, “Topi-CLICK Perl® was developed because pharmacists, healthcare providers, and patients expressed the need for an improved vaginal dosing method that performed with the same accuracy and consistency as our Topi-CLICK 35® topical dosing applicator. As an innovator in the industry since 2007, we’ve devoted years of research and development into designing and manufacturing the best metered-dosing applicators in the market. This latest Feminine Dosing Study by ARL confirms that Topi-CLICK Perl® will deliver a more accurate, consistent and easier-to-use vaginal dose than traditional methods and therefore should be a real gamechanger in improving treatment outcomes.”

¹Request the complete study, Single-Blinded Feminine Dosing Study, conducted by Analytical Research Laboratories at /PerlAccuracy_study.

About DoseLogix
DoseLogix, based in Woodstock (Atlanta), Ga., manufactures a variety of topical dosing applicators to support its flagship brand, Topi-CLICK®, including the Topi-CLICK® 35, the larger volume Topi-CLICK® 140, the revolutionary Topi-CLICK Perl® Vaginal Dosing System and the new micro-dosing Topi-CLICK Micro®. For further information on our products, please visit, call 1.800.870.8448 or email [email protected].


Media contact: DoseLogix Marketing, 877.870.8448